Research at Shepherd Center

A Randomized Trial to Compare Effectiveness of Two Interventions for Caregivers of Patients with Acquired Brain Injury

• Principal Investigator: Michael Jones
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Altered Central Multisensory Processing in Post-concussion Vestibular Dysfunction

• Principal Investigator: Russell Gore
• Sponsor: National Institutes of Health (NIH)

BCVI Screening Practices of Acute Care Hospitals in Shepherd Center’s Catchment Area

• Principal Investigator: Yevgeniya Sergeyenko
• Sponsor: Unfunded

Characterization of Post-concussive Vestibular Impairment Brain Structural and Functional Connectivity Dysfunction and the Impact of Vestibular Rehabilitation

• Principal Investigator: Russell Gore
• Sponsor: Unfunded

Documenting the General Effectiveness of Recreational Therapy Services for Individuals with Acquired Brain Injury

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded

Drive Safe: Driving Safety in Adolescents and Young Adults after Concussion

• Principal Investigator: Russell Gore
• Sponsor: Andee's Army Foundation

Evaluating the Effectiveness of a Least Restrictive Restraint Training Program for Individuals with ABI

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded

Evaluation of SHARE Military Initiative Program Outcomes: Understanding the Relationship Between Patient Characteristics and Effectiveness of Clinical Care

• Principal Investigator: Tracey Wallace
• Sponsor: Unfunded

Evaluation of Vitamin D Goal Level Achievement in Brain Injury Patients at an Inpatient Rehabilitation Center?

• Principal Investigator: Elisabeth Webb
• Sponsor: Unfunded

GAMBIS Site-Specific Study: Improving Employment Outcomes of Persons with Moderate/Severe TBI

• Principal Investigator: Brick Johnstone
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

GAMBIS: A Longitudinal Study of Individuals with Moderate/Severe TBI

• Principal Investigator: Brick Johnstone
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Improving Access to Comprehensive TBI Treatment for Military Veterans and Service Members with Co-occurring Substance Use

• Principal Investigator: Russell Gore
• Sponsor: Unfunded

Magnetic Resonance Spectroscopy Applications in Disorders of Consciousness (MRS for DoC)

• Principal Investigator: Candace Fleischer
• Sponsor: Unfunded

Rehabilitation Pathways after Concussion: A Retrospective Chart Review of Referral for Cognitive-Communication Services

• Principal Investigator: Tracey Wallace
• Sponsor: Unfunded

Rehabilitation Pathways after Concussion: Understanding Management of Cognitive Communication Complaints

• Principal Investigator: Tracey Wallace
• Sponsor: Unfunded

Shepherd Center – Foundation to Advance Brain Rehabilitation Post-Acute Rehabilitation Outcome Study

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded

SUCCESS: Success in College after Concussion with Effective Student Supports

• Principal Investigator: Tracey Wallace
• Sponsor: Unfunded

The Application of BCVI Screening Criteria to Post-Acute Patients with Traumatic Brain Injury

• Principal Investigator: Yevgeniya Sergeyenko
• Sponsor: Unfunded

Transcranial Direct Current Stimulation Paired with Exercise and Attention Training Compared with Exercise Alone with Attention Training for Mild Traumatic Brain Injury

• Principal Investigator: April Hodge
• Sponsor: Unfunded

Veteran Goal Directed Comprehensive Care Outcomes in Chronic Mild Traumatic Brain Injury

• Principal Investigator: Tracey Wallace
• Sponsor: Unfunded

AutoCoach Evaluation

• Principal Investigator: Emma Harrington
• Sponsor: Unfunded

Disability and Rehabilitation Research Project (DRRP): App Factory

• Principal Investigator: Mike Jones
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Internal Consistency of the Functional Impact Tool for Mobility Devices

• Principal Investigator: Mandy McDonald
• Sponsor: Unfunded

LiveWell RERC: Tech Factory

• Principal Investigator: John Morris
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Pilot Study to Validate Assessment of Fatigue Using Wearable Inertial Measurement Unit Sensors

• Principal Investigator: Brad Willingham
• Sponsor: Unfunded

RERC on Mobile Rehabilitation: Clinician Perceptions on Use of Information and Communication Technologies to Support Home-Based Therapy and Exercise

• Principal Investigator: John Morris
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Usability Lab: Technology Access Feedback for Intel

• Principal Investigator: John Morris
• Sponsor: Intel

User Testing of MagTrack Motion Tracking Inertial Measurement Electronics Controller

• Principal Investigator: John Morris
• Sponsor: Georgia Research Alliance

UXLab- McDonalds-206-Kiosk Reach Mode

• Principal Investigator: John Morris
• Sponsor: McDonalds

UXLab-Microsoft-9025-Flash Feedback PWD

• Principal Investigator: John Morris
• Sponsor: Microsoft

Green Spaces and Park Survey

• Principal Investigator: Raeda Anderson
• Sponsor: Accessibility User Research Collective (AURC)

A Double-blind, Randomized, Placebo-controlled, Parallel-group Trial of the Efficacy and Safety of Nabiximols Oromucosal Spray as Add-on Therapy in Patients with Spasticity Due to Multiple Sclerosis

• Principal Investigator: Ben Thrower
• Sponsor: GW Pharmaceuticals

A Phase 1, Dose-Escalating, Open-label Study to Evaluate the Safety, Tolerability, and Exploratory Efficacy of Single Dose of IV IMS001 in Subjects with Multiple Sclerosis and Treatment Failure to Prior Disease Modifying Treatments (DMTs)

• Principal Investigator: Ben Thrower
• Sponsor: ImStem Biotechnology

A Therapeutic Experience Program (TEP) Study Assessing Adherence to On-Label PoNS® Therapy for Improvement of Gait in People with Multiple Sclerosis (MS) in a Real-World Clinical Setting

• Principal Investigator: Deborah Backus
• Sponsor: Helius Medical Technologies

AGNOS: An 18-month, Open-label, Multi-Center Phase IV Study to Assess the Effect of Ofatumumab 20mg SC Monthly in Treatment Naïve, Very Early Relapsing Remitting Multiple Sclerosis Patients Benchmarked Against Healthy Controls on Select Outcomes

• Principal Investigator: Jacqueline Rosenthal
• Sponsor: Novartis

An Observational Study of Ocrelizumab Treated Patients with Multiple Sclerosis to Determine the Incidence and Mortality Rates of Breast Cancer and All Malignancies

• Principal Investigator: Ben Thrower
• Sponsor: ROCHE

An Open-Label, Multicenter Study To Assess Disease Activity And Biomarkers Of Neuronal Damage In Minority Patients With Relapsing Multiple Sclerosis Receiving Treatment With Ocrelizumab

• Principal Investigator: Ben Thrower
• Sponsor: Genentech, Inc

An Open-Label, Single-Arm Study To Evaluate The Effectiveness And Safety Of Ocrelizumab In Patients With Early Stage Relapsing Remitting Multiple Sclerosis (Protocol # MA30143)

• Principal Investigator: Ben Thrower
• Sponsor: F. Hoffman-La Roche LTD

Comparative Effectiveness of an Exercise Intervention Delivered via Telerehabilitation and Conventional Mode of Delivery

• Principal Investigator: Deborah Backus
• Sponsor: PCORI

CorEvitas SPHERES (Synergy of Prospective Health & Experimental Research for Emerging Solutions) Registry for Neuromyelitis Optica Spectrum Disorder (NMOSD)

• Principal Investigator: Jacqueline Rosenthal
• Sponsor: CorEvitas

Developing an Integrated Remote Monitoring System to Inform the Calibration of Rehabilitation and Exercise Interventions for People with Multiple Sclerosis

• Principal Investigator: Brad Willingham
• Sponsor: Unfunded

Exploring Barriers to Multiple Sclerosis (MS) Diagnosis and Treatment for Black or African Americans with MS Compared to White Americans with MS

• Principal Investigator: Louise Palmer
• Sponsor: Consortium of MS Centers

Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients with Progressive Multiple Sclerosis- CALLIPER Study

• Principal Investigator: Jacqueline Rosenthal
• Sponsor: Immunic AG

Pilot Study Evaluating Functional and Wellness Outcomes of the Shepherd Can Do MS Program

• Principal Investigator: Deborah Backus
• Sponsor: Genzyme Corporation

Pilot Study to Validate Assessment of Fatigue using Wearable Inertial Measurement Unit Sensors

• Principal Investigator: Brad Willingham
• Sponsor: Unfunded

Qualitative Evaluation of the STEP for MS Trial

• Principal Investigator: Deborah Backus
• Sponsor: Unfunded

Safety, Feasibility, and Usability of Tele-exercise with BurnAlong in Persons with Multiple Sclerosis; a Pilot Study

• Principal Investigator: Deborah Backus
• Sponsor: Unfunded

Shepherd Center MS Outcomes Data Registry

• Principal Investigator: Deborah Backus
• Sponsor: Unfunded

A Longitudinal fMRI study of Theistic Relational Processing in Individuals with Neurologic Dysfunction

• Principal Investigator: Brick Johnstone
• Sponsor: Shirley Ryan Ability Lab (through the John Templeton Foundation)

Documenting Relationships Between Satisfaction with Telehealth Services and Rural/Urban Status for Individuals with Chronic Disabilities

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded

Evaluating the Effectiveness of Brain Health Training for Individuals with SCI/TBI and their Family Members

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded

Evaluation of Oscillation and Lung Expansion (OLE) Using The Volara® System for Treatment of Respiratory Complications in Patients with Neuromuscular Disease in the Home Setting

• Principal Investigator: Philip Wexler
• Sponsor: Hill-Rom (Science 37)

Experience and Perceptions of the Talent Development Environment Questionnaire for Athletes with Physical Disabilities

• Principal Investigator: Andrew Corbett
• Sponsor: Unfunded

Scale Up Trial of Project WOWii to Increase Exercise among People with Spinal Cord Injury (SCI)

• Principal Investigator: Michael Jones
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Sociocultural Determinants of Recovery, Health, and Community Participation in Asian Americans with Disabilities

• Principal Investigator: Jessica Conklin
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR) Switzer Fellowship Program (pending)

Validation of a Neuropsychological Model of Disorders of the Self

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded

Shepherd Center Neuropsychology Data Registry Research Protocol

• Principal Investigator: Kristian Nitsch
• Sponsor: Unfunded

Pain Outcomes in Patients with Chronic Pain After the Implantation of the Nalu™ Peripheral Nerve Stimulator Erik Shaw, DO - Derick Carmicheal Davis, M.D.

• Principal Investigator: Erik Shaw
• Sponsor: Unfunded

Patient Retrospective Outcomes (PRO) Clinical Investigation Plan

• Principal Investigator: Erik Shaw
• Sponsor: Boston Scientific

Radiofrequency (RF) Ablation Prospective Outcomes Study (RAPID)

• Principal Investigator: Erik Shaw
• Sponsor: Boston Scientific

Days of Intravenous Vancomycin Therapy in Patients with Pneumonia after Negative MRSA Nasal Screens

• Principal Investigator: Lauren Wilcox
• Sponsor: Unfunded

A Long-term Follow-up Study of Subjects with Cervical Spinal Cord Injuries Who Received AST-OPC1 in Protocol AST-OPC1-01 Asterias AST-OPC1-02

• Principal Investigator: Donald Peck Leslie
• Sponsor: Lineage Cell Therapeutics

A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of MT-3921 in Subjects with Acute Traumatic Cervical Spinal Cord Injury Protocol Number: MT-3921-A01

• Principal Investigator: Donald Peck Leslie
• Sponsor: Mitsubishi Tanabe Pharma Development America Inc.

A Prospective Multicenter, Longitudinal, Cohort Study to Assess the Measurement Properties of Clinical Outcomes Assessments in Patients with Traumatic Low Cervical Spinal Cord Injury / Protocol MT-3921-A-00

• Principal Investigator: Casey Kandilakis
• Sponsor: Mitsubishi Tanabe Pharma Development America Inc. (MTDA)

A Randomized, Double-Blind, Placebo-Controlled Proof of Concept Study to Assess the Safety and Efficacy of Elezanumab in Acute Traumatic Cervical Spinal Cord Injury

• Principal Investigator: Michael Yochelson
• Sponsor: Abbvie

Antecedents, Consequences, and Interventions for Travel Participation After SCI

• Principal Investigator: Edelle Field-Fote
• Sponsor: University of Indiana (Craig H Neilsen Foundation)

Comparing Bihemispheric Excitatory Non-Invasive Brain Stimulation Modalities for Improvement of Bimanual Function in Persons with Tetraplegia

• Principal Investigator: Jennifer Iddings
• Sponsor: Unfunded

Discovery of Biomarker Signatures Prognostic for Neuropathic Pain after Acute Spinal Cord Injury (BSCIP). Protocol Number: HSC-MS-19-0258 Principal Investigators: UT: Georgene W. Hergenroeder, PhD Grady/Emory: Faiz Ahmad, M.D.

• Principal Investigator: Faiz Ahmad (Yochelson)
• Sponsor: University of Texas Health Science Center at Houston; NINDS

Evaluating Technologies for Monitoring Skin Changes Across Skin Tones

• Principal Investigator: Sharon E. Sonenblum
• Sponsor: Unfunded

Improving Quality of Personal Care Assistance Services for People with SCI through Online Education

• Principal Investigator: John Morris
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Neuromodulation of Spinal Circuits: Effects on Spasticity, Nociception, and Motor Activation

• Principal Investigator: Edelle Field-Fote
• Sponsor: Unfunded

Protocols # CP35A007 and CP35A008 Protocols # CP35A007 A Phase 1 Safety Study of GRNOPC1 in Patients with Neurologically Complete, Subacute Spinal Cord Injury Protocol #CP35A008 Long term Follow Up of Subjects Who Received GRNOPC1

• Principal Investigator: Wesley Chay
• Sponsor: Lineage Cell Therapeutics (formerly Asterias and Geron) # CP35A007 & #CP35A008

SCI Model Systems of Care Data Collection and Transmission

• Principal Investigator: Edelle Field-Fote
• Sponsor: Unfunded

SCIMS Site Specific Project: Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity

• Principal Investigator: Edelle Field-Fote
• Sponsor: National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR)

Single-group Pretest-Postest Study of Shepherd's Get Your Verve Back Virtual Wellness and Leisure Program

• Principal Investigator: Jenny DiLaura
• Sponsor: Unfunded

Systemic Hypothermia in Acute Cervical Spinal Cord Injury A Prospective, Multi-center Case Controlled Study

• Principal Investigator: David Gimbel (Yochelson)
• Sponsor: DOD - Shepherd not funded

Unintentional Injuries

• Principal Investigator: James Krause
• Sponsor: Unfunded

Spinal Cord Neuromodulator by SpineX and SCONE to Treat Neurogenic Bladder (SCONE “CONTINENCE” Clinical Study)

• Principal Investigator: Rita Jen
• Sponsor: SpineX

Documenting the General Effectiveness of Chaplaincy Services for Individuals with Chronic Disabilities

• Principal Investigator: Brick Johnstone
• Sponsor: Unfunded